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Biotrak Assays for Alzeihmer’s Disease and Parkinson’s disease


Formation of senile plaques
b-amyloid 1-42,
b-amyloid 1-40

Formation of Lewy bodies
b-synuclein

Located in regions of mature amyloid
filaments, contributes to neuronal degradation
IL-1

Released by activated microglia (activated
by α-amyloid) damages brain tissue,
inflammatory cascade
PGE2, IL-1, IL-6

Potentiate microglia activation
IFNg, TNFb

b-amyloid enhances vasoconstriction
induced by ET-1, blocked by cGMP PDE
ET-1, cGMP

Impaired cAMP signalling
cAMP

Increased levels in CSF
IL-1b


Formation of senile plaques

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Formation of Lewy bodies

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Located in regions of mature amyloid filaments, contributes to neuronal degradation

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Released by activated microglia (activated by α-amyloid) damages brain tissue, inflammatory cascade

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Potentiate microglia activation

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b-amyloid enhances vasoconstriction induced by ET-1, blocked by cGMP PDE

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Impaired cAMP signalling

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Increased levels in CSF

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