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Biotrak Assays for Liver Disease, Cirrhosis, Fibrosis

Categories of Mediators	Biotrak™ Assays
Metabolic enzymes Cytochrome	P450s
Inflammatory cytokines/mediators	MMP-9
released by Kupffer cells	TNFa, IL-6,
Fibrosis	TGFb, TIMPs
Inhibit growth of myofibroblastic Endothelins, hepatic stellate cells	TNFa, PGE2
Produced by stellate cells in hepatitis, cirrhosis, fibrosis	TIMP-1
Induce leucocyte recruitment into liver microcirculation	LTC4
Suppress oxygen consumption, inhibit glucose production	PAF
Anti-inflammatory agents	cAMP

Metabolic enzymes Cytochrome

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Inflammatory cytokines/mediators

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released by Kupffer cells

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Fibrosis

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Inhibit growth of myofibroblastic Endothelins, hepatic stellate cells

Produced by stellate cells in hepatitis, cirrhosis, fibrosis

Induce leucocyte recruitment into liver microcirculation

Suppress oxygen consumption, inhibit glucose production

Anti-inflammatory agents

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