Application areas
Enzyme assays>
Enzme SPA applications can be used to identify potential new enzyme inhibitors, measure enzyme activity, and perform kinetic analysis.
Kinase assays>
Kinases play pivotal roles in many signal transduction cascades and consequently kinase activities remain a key focus of academic and pharmaceutical research. The SPA beads can be used in the studyof tyrosine and serine/threonine kinases using both peptide and protein substrates
Receptor Binding assays>
Receptor-binding SPAs can be configured to determine receptor kinetics, saturation binding, or to detect inhibitors of radioligand binding. SPA has been successfully applied to receptor-binding assays by immobilizing receptors directly to SPA beads via a number of coupling methods.
Molecular interaction research>
SPA technology has been successfully applied to the study of a variety of molecular interactions. Protein:protein interactions. Protein: peptide interactions. Protein: DNA interactions Cell adhesion molecule interactions.
Radioimmunoassays>
SPA radioimmunoassay is based on the reaction of antibody-bound ligand with SPA beads coated with either a secondary antibody or Protein A.
Cell based assays>
Cytostar-T™ Scintillating Microplates have been developed specifically for the study of cell-based assays using SPA technology. Cytostar-T Scintillating Microplates can be utilized in non-invasive and real time analysis of cellular events.
Drug Metabolism and Pharmacokinetics>
DMPK assays are a range of kits for use in drug metabolism and pharmacokinetic studies. DMPK assays provide an economical and higher throughput alternative to conventional assay methodologies such as equilibrium dialysis, HPLC, and ultrafiltration.
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