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Two-step purification of monoclonal antibodies with Capto adhere and MabSelect SuRe

The increasing demand for monoclonal antibodies (MAbs) as biopharmaceuticals has promoted the development of cell cultures with increased expression levels. As a consequence, the demand for more efficient purification processes has increased.

Capto™ adhere is a multimodal BioProcess™ medium designed for post-protein A purification of monoclonal antibodies (MAbs) at process scale. Capto adhere can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step, allowing the design of a two-step process together with MabSelect SuRe™.


Capto adhere offers:

  • Contaminant removal to formulation levels in post protein A purification
  • High capacity and productivity in flow-through mode
  • Wide operational window of pH and conductivity
  • Savings in time and operating costs with a two-step chromatographic process

Read more about Capto adhere.