Multimodal chromatography

Multimodal ligands interact with target molecules through multiple types of interaction. Ionic interactions are commonly involved, but others such as hydrogen bonding and hydrophobic interactions can be significant. The strength of these individual interactions often depends on the overall process conditions.

Media containing multimodal ligands are characterized by selectivities that are different from those of “traditional” ligands, thereby opening up new opportunities for solving challenging purification problems.

Capto™ MMC
A multimodal cation exchanger. Has a novel selectivity and allows protein binding at high conductivities.

Capto adhere
A multimodal anion exchanger. For intermediate purification and polishing of monoclonal antibodies after capture on Protein A affinity media.

PlasmidSelect Xtra
Aromatic and thiophilic adsorption interactions predominate. Forms the basis of a generic process for purifying supercoiled, covalently-closed circular plasmid DNA.