 |
The MAb purification challenge
The most significant recent improvement in monoclonal antibody (MAb) purification is the increasing titer concentrations from low milligrams to multi-grams per liter. Since the mid 1980s, titre concentrations have increased from less than 0.1 g/L to current levels at 2 to 6 g/L. The increase is expected to continue to up to 10 g/L in the near future. The continuing increase in titer concentrations has led to problems in the form of increased cell debris and increased contaminant (e.g., host cell proteins, DNA, viruses, dimmers and aggregates) levels. Thus, a clear challenge facing the industry is reducing the high level of contaminants that invariably accompanies current MAb purification processes.
Figure above shows the recent increase in MAb antibody titer development.
GE Healthcare offers a range of media that have provided significant improvement in the purification of MAbs. Read more about it in the MAb purification toolbox. |
 |
|
